2020 Publications on Tethered Lipid Bilayer Membranes

Improved micro-impedance spectroscopy to determine cell barrier properties

Md. Mehadi Hassan Sohag, Oliver Nicoud, Racha Amine, Abir Khalil-Mgharbel, Isabelle Vilgrain, Donald K Martin

The Eurobiotech Journal Vol 4 Issue 3 July2020   doi: 10.2478/ebtj-2020-0017


2018 Publications on Tethered Lipid Bilayer Membranes


A biomemetic lipid membrane device reveals interaction of cancer biomarkers with human serum lipidic moieties

Abir Khalil-Mgharbel, Helena Polena, Paul K. Demb_el_e, Md. Mehadi Hassan Sohag, Jean Pierre Alcaraz, , Donald K Martin, Isabelle Vilgrain

Biotechnol. J, 2018, 13, 1800463 doi: 10.1002/biot.201800463

The effect of hydronium ions on the structure of phospholipid membranes

Evelyne Deplazes, David Poger, Bruce Cornell, Charles Cranfield

Phys Chem Chem Phys Issue 1 2018    doi: 10.1039/C7CP06776C

2017 Publications on Tethered Lipid Bilayer Membranes 

Pore forming peptides

Kalata B1 and Kalata B2 have a Surfactant-Like Activity in Phosphatidylethanolamine-Containing Lipid Membranes

Charles Cranfield, Sonia Troeira Henriques, Boris Martinac, Paul Duckworth, David Craig, Bruce Cornell

Langmuir, 2017, 33 (26), pp 6630–6637  doi: 10.1021/acs.langmuir.7b01642

Design and synthesis of short amphiphilic cationic peptidomimetics based on biphenyl backbone as antibacterial agents

Rajesh Kuppusamy et al. European Journal of Medicinal Chemistry 2017 in press 

Membrane Biophysics

The effect of Cholesterol on the Dielectric Structure of Lipid Membranes

Adeel Alobeedallah, Bruce Cornell, Hans Coster

The Journal of Membrane Biology 29 November 2017


2016 Publications on Tethered Lipid Bilayer Membranes 

Pore forming peptides

Candidalysin is a fungal peptide critical for mucosal infection

David L Moyes et al 

Nature 2016 532 64-68  doi:10.1038/nature17625

Membrane Biophysics

The Effect of Benzyl Alcohol on the Dielectric Structure of Bilayers

Hadeel Alobeedallah, Bruce Cornell, Hans Coster

The Journal of Membrane Biology;  November 2016, doi: 10.1007/s00232-016-9934

The Effect of Tethers on Artificial Cell Membranes: A Coarse-Grained Molecular Dynamics Study.

Hoiles W, Gupta R, Cornell B, Cranfield C, Krishnamurthy V

PLoS One  2016 Oct 13;11(10):e0162790. doi: 10.1371/journal.pone.0162790. eCollection 2016

Evidence of the Key Role of H3O+ in Phospholipid Membrane Morphology

Charles G. Cranfield, Thomas Berry, Stephen A. Holt, Khondker R. Hossain, Anton P. Le Brun, Sonia Carne, Heba Al Khamici, Hans Coster, Stella M. Valenzuela, and Bruce Cornell

Langmuir, 2016, 32 (41), pp 10725–10734  doi: 10.1021/acs.langmuir.6b01988

Ion Channels

Investigating Sterol and Redox Regulation of the Ion Channel Activity of CLIC1 Using Tethered Bilayer Membranes

Heba Al Khamici 1, Khondker R. Hossain 1,2, Bruce A. Cornell 3 and Stella M. Valenzuela

Membranes 2016, 6(4), 51; doi:10.3390/membranes6040051

Elucidating the Mechanism for Sterol Regulation of Chloride Intracellular Ion Channel Protein Interactions with Lipid Membranes

Khondker R. Hossain, Heba Al Khamici, Stephen A. Holt, Stella M. Valenzuela

Biophysical Journal Volume 110, Issue 3, Supplement 1, p204a, 16 February 2016  doi;

2015 Publications 

The assembly and use of tethered bilayer lipid membranes (tBLMs).
Cranfield C1, Carne S, Martinac B, Cornell B.   Methods Mol Biol. 2015;1232:45-53.
doi: 10.1007/978-1-4939-1752-5_4.

Nanoscale Ion Sequestration To Determine the Polarity Selectivity of Ion Conductance in Carriers and Channels

Charles G. Cranfield, Taren Bettler, and Bruce Cornell

Langmuir, 2015, 31 (1), pp 292–298  doi: 10.1021/la504057z

Modelling the Bioelectronic Interface in Engineered Tethered Membranes: From Biosensing to Electroporation

 William Hoiles  Vikram Krishnamurthy  Bruce Cornell

IEEE Transactions on Biomedical Circuits and Systems ( Volume: 9, Issue: 3, June 2015 ) 321 - 333  doi: 10.1109/TBCAS.2014.2357420

The Effect of Bias Potential on Tethered Lipid Bilayers

Stephen Holt et al

2nd Asia Oceania Conference on Neutron Scattering 2015

Earlier Publications



Supported Membranes: Scientific and Practical Applications. E. Sackmann. Science 5 January 1996: 43-48. doi:10.1126/science.271.5245.43


Ion Channels

Comparative Study of the Bacterial Sodium Channel NaChBac Function using Patch Clamp and A.C. Impedance Spectroscopy in a Tethered Membrane. BruceA.Cornell, Gwenael Scolan, Andrew M. Powl, Sonia Carne, Bonnie Wallace. Biophysical Journal, 102,3,338a,2012 DOI:10.1016/j.bpj.2011.11.1852

The protective effect of osmoprotectiveTMAO on bacterial mechanosensitive channels of small conductive MscS/MscK under high hydorstatic pressure. Evgeny Petrov, Paul  Rohde, Bruce Cornell, and Boris Martinac. Channels, 6:4, 1-10, 2012 DOI: 10.4161/chan.20833

Ion Channel Proteins that Spontaneously Insert into Lipid Bilayer Membranes: An Impedance Spectroscopy Study Employing Tethered Membranes.
Bruce A. Cornell, Heba Alkhamici, Louise Brown, Sonia Carne, Sophia C. Goodchild, Russell Richards, and Stella M. Valenzuela. Biophysical Journal, 102, 682a-683a, 2012. DOI: 10.1016/j.bpj.2011.11.3710


A High-Throughput Technique for Screening Novel Antibacterial Agents Targeting Bacterial Mechanosensitive Channels.
Bruce A. Cornell, Andrew R. Battle, Sonia Carne, and Boris Martinac. Biophysical Journal, 102,122a, DOI: 10.1016/j.bpj.2011.11.683


Regulation of the Membrane Insertion and Conductance Activity of the Metamorphic Chloride Intracellular Channel Protein CLIC 1 by Cholesterol.  Valenzuela, Stella M; Alkhamici, Heba; Brown, Louise J,; et al. PLOS ONE Volume 8 Issue 2 Article Number e56948 Feb 14,2013


Bacterial Mechanosensitive Channels: Models for Studying Mechanosensitive Transduction.  Martinac, Boris; Nomura, Takeshi; Chi Gamma; et al. Antioxidants and Redox Signalling Volume: 20 Issue: 6 Pages: 952-969 Feb 20, 2014



Making lipid membranes even tougher. Jognandan Prashar, Phillip Sharp, Mathew Scarffe, and Bruce Cornell. Journal of Materials Research, 22, 2189-2194, 2007. DOI: 10.1557/jmr.2007.0288


Tethered Bilayer Membranes Containing Ionic Reservoirs:  Selectivity and Conductance. Gowri Krishna, Jurgen Schulte, Bruce A. Cornell, Ron J. Pace, and Peter D. Osman. Langmuir, 19, 2294–2305, 2003. DOI: 10.1021/la026238d

Tethered Bilayer Membranes Containing Ionic Reservoirs:  The Interfacial Capacitance. Gowri Krishna, Jurgen Schulte, Bruce A. Cornell, Ron Pace, Lech Wieczorek, and Peter D. Osman. Langmuir, 17, 4858–4866, 2001. DOI: 10.1021/la001480a


Tethered-bilayer lipid membranes as a support for membrane-active peptides. B. A. Cornell, G. Krishna, P. D. Osman, R. D. Pace and L. Wieczorek. Biochemical Society Transactions, 29, 613–617, 2001. DOI: 10.1042/bst0290613

Tethered Lipid Bilayer Membranes: Formation and Ionic Reservoir Characterization. Burkhard Raguse, Vijoleta Braach-Maksvytis, Bruce A. Cornell, Lionel G. King, Peter D. J. Osman, Ron J. Pace, and Lech Wieczorek. Langmuir, 1998, 14, 648–659 1998. DOI: 10.1021/la9711239


A study of Functional Ion Transport Using Tethered Membranes. Cornell, Bruce A; Battle Andrew; Brown, Louise; et al.  Biophysical Journal Volume: 100 Issue:3 Supplement 1 Page 338 Feb 2011


Biomimetic Membrane System Composed of a Lipid Bilayer Supported by an Interpenetrating Hydrogel for Usage as Replacement Membranes in Diffusion Chambers.  Martin, Donald K; Alcarez, Jaen-Pierre; Stidder, Barry; et al. Abstracts of Papers of the American Chemical Society Volume: 245  Meeting Abstract 10-PHYS April 2013

An engineered membrane to measure electroporation: Effect of tethers and bioelectronic interface

William Hoiles, Vikram Krishnamurthy, Charles G. Cranfield, Bruce Cornell

Biophysical Journal  Volume 107, Issue 6, 16 September 2014, Pages 1339–1351



A biosensor that uses ion-channel switches.   Cornell BA, BraachMaksvytis VLB, King LG, et al.   NATURE Volume: 387 Issue: 6633 Pages: 580-583 Published: JUN 5 1997


The ion channel switch biosensor.  Woodhouse G, King L, Wieczorek L, et al.  JOURNAL OF MOLECULAR RECOGNITION Volume: 12 Issue: 5 Pages: 328-334 Published: SEP-OCT 1999


Kinetics of the competitive response of receptors immobilised to ion-channels which have been incorporated into a tethered bilayer. Woodhouse GE, King LG, Wieczorek L, et al. FARADAY DISCUSSIONS Volume: 111 Issue: 111 Pages: 247-258 Published: 1998


Gramicidin ion channel-based biosensors: Construction, Stochastic dynamical models, and statistical detection algorithms. Krishnamurthy V, Luk KY, Cornell B, et al. IEEE SENSORS JOURNAL Volume: 7 Issue: 9-10 Pages: 1281-1288 Published: SEP-OCT 2007


Rapid detection of influenza A virus in clinical samples using an ion channel switch biosensor.  Oh SY, Cornell B, Smith D, et al.  BIOSENSORS & BIOELECTRONICS Volume: 23 Issue: 7 Pages: 1161-1165 Published: FEB 28 2008


Reconfigurable Ion-Channel based Biosensor: Input Excitation Design and Analyte Classification. Monfared, Sahar M.; Krishnamurthy, Vikram; Cornell, Bruce Proceedings of the 48th IEEE Conference on Decision and Control (CDC) / 28th Chinese Control Conference (CCC) Location: Shanghai, PEOPLES R CHINA Date: DEC 15-18, 2009


Mathematical modeling of a tethered bilayer sensor containing gramicidin A ion channels. Monfared, Sahar M; Krishnamurthy, Vikram; Cornell, Bruce  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference  Volume: 2009   Pages: 1262-5    2009


tochastic modeling and signal processing of nano-scale protein-based biosensors Monfared, Sahar M.; Krishnamurthy, Vikram; Cornell, Bruce. 7th IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS 2009).2009 IEEE INTERNATIONAL WORKSHOP ON GENOMIC SIGNAL PROCESSING AND STATISTICS (GENSIPS 2009)  Pages: 154-159    2009


hemical Kinetics and Mass Transport in an Ion Channel Based Biosensor. Monfared, Sahar M.; Krishnamurthy, Vikram; Cornell, Bruce C.  49th IEEE Conference on Decision and Control (CDC) Location: Atlanta, GA, DEC 15-17, 2010.  49TH IEEE CONFERENCE ON DECISION AND CONTROL (CDC)  Book Series: IEEE Conference on Decision and Control   Pages: 4685-4690    2010


on Channel Biosensors Part I Construction Operation and Clinical Studies.  Krishnamurthy V, Monfared SM, Cornell B.  IEEE Transactions on Nanotechnology May 2010 Volume 9 No 3: Pages: 303-313   MAY 2010


Ion Channel Biosensors Part II Dynamic Modelling, Analysis and Statistical Signal Processing.  Krishnamurthy V, Monfared SM, Cornell B.  Transactions on Nanotechnology May 2010 Volume 9 No 3: Pages: 313-322  MAY 2010


Engineering aspects of biological ion channels-from biosensors to computational models for permeation .   Krishnamurthy, Vikram; Cornell, Bruce PROTOPLASMA  Volume: 249   Supplement: 1   Pages: S3-S9   Published: FEB 2012


A molecular machine biosensor: Construction, predictive models and experimental studies Moradi-Monfared, Sahar; Krishnamurthy, Vikram; Cornell, Bruce

BIOSENSORS & BIOELECTRONICS  Volume: 34   Issue: 1   Pages: 261-266   Published: APR 15 2012


Multiple Surface-Based Biosensors for Enhanced Molecular Detection in Fluid Flow Systems Abolfath-Beygi, Maryam; Krishnamurthy, Vikram; Cornell, Bruce  IEEE SENSORS JOURNAL  Volume: 13   Issue: 4   Pages: 1265-1273   Published: APR 2013


Small peptides and membrane pore forming biomaterials

A tethered bilayer sensor containing alamethicin channels and its detection of amiloride based inhibitors.  Yin P, Burns CJ, Osman PDJ, et al.  BIOSENSORS & BIOELECTRONICS Volume: 18 Issue: 4 Pages: 389-397  APR 2003


Tethered-bilayer lipid membranes as a support for membrane-active peptides.   Cornell BA, Krishna G, Osman PD, et al.  BIOCHEMICAL SOCIETY TRANSACTIONS Volume: 29 Pages: 613-617 Part: Part 4  AUG 2001


A High-Throughput Technique for Screening Novel Antibacterial Agents Targeting Bacterial Mechanosensitive Channels. Cornell, Bruce A.; Battle, Andrew R.; Carne, Sonia; et al.   56th Annual Meeting of the Biophysical-Society Location: San Diego, CA Date: FEB 25-29, 2012   BIOPHYSICAL JOURNAL  Volume: 102   Issue: 3   Supplement: 1   Pages: 122A-122A   JAN 31 2012 doi:10.1016/j.bpj.2011.11.683


Characterization of Antimicrobial Peptide Insertion in Tethered Bilayer Lipid Membranes by Pulse Amperometry and Linear Sweep Voltammetry Methods Cranfield, Charles G.; Cornell, Bruce; Grage, Stephan L.; et al.   Conference: 57th Annual Meeting of the Biophysical-Society Location: Philadelphia, PA Date: FEB 02-06, 2013 BIOPHYSICAL JOURNAL  Volume: 104   Issue: 2   Supplement: 1   Pages: 600A-600A    JAN 29 2013 doi:10.1016/j.bpj.2012.11.3330


Transient Potential Gradients and Impedance Measures of Tethered Bilayer Lipid Membranes: Pore-Forming Peptide Insertion and the Effect of Electroporation. Cranfield, Charles G.; Cornell, Bruce A.; Grage, Stephan L.; et al.   BIOPHYSICAL JOURNAL  Volume: 106   Issue: 1   Pages: 182-189   Published: JAN 7 2014 doi:10.1016/j.bpj.2013.11.1121


Screening the Insertion of Families of Bioactive Microbial Metabolites into Tethered Bilayer Lipid Membranes (TBLMS). Cranfield, Charles G.; Carne, Sonia; Alkhamici, Heba; et al. 58th Annual Meeting of the Biophysical-Society Location: San Francisco, CA Date: FEB 15-19, 2014 BIOPHYSICAL JOURNAL  Volume: 106   Issue: 2   Supplement: 1   Pages: 294A-294A   JAN 28 2014 doi:10.1016/j.bpj.2013.11.1714.

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